Flexeril, Baclofen, Methocarbamol, and Tizanidine

Calls to our general hotline may be answered by private treatment providers. We may be paid a fee for marketing or advertising by organizations that can assist with treating people with substance use disorders. Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph. Flexeril especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. To view a report comparing 3 (or more) medications, please sign in or create an account.

One advantage of Baclofen in Methocarbamol vs Baclofen comparison is that it can be used as a treatment for the medical condition called Trigeminal Neuralgia, a type of chronic pain in the face. So, for those wondering which is better in Robaxin vs Baclofen, consider first the other medical conditions of the patient. Then, analyze if the patient can tolerate the side effects of the drug to be used. For a safer and more effective treatment, always consult a medical professional.

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Onset of action is 30 minutes following oral ingestion and almost immediate following parenteral administration. Methocarbamol is produced in 500- and 750-mg tablets and has a recommended dosage range of 4000 to 4500 mg daily in 3 or 4 divided doses. For severe conditions, dosage as high as 6 to 8 g may be given for the first 48 to 72 hours. This drug is available for IV or IM injection in 10-mL single-dose vials containing 10 mg/mL. Methocarbamol tablets are also available in combination with aspirin (Robaxisal). Conditions treated by Robaxin and Flexeril are almost the same, such as muscle spasms, pain, injury.

Side Effects and Precautions

While it is effective for many individuals, its muscle relaxant effects may be milder than those of Cyclobenzaprine. The decision to prescribe Methocarbamol and Cyclobenzaprine together requires a thorough assessment of the individual’s medical history, current medications, and specific treatment conditions. Healthcare professionals carefully weigh the potential benefits against the risks and monitor patients closely to ensure their safety. Addiction Resource is an educational platform for sharing and disseminating information about addiction and substance abuse recovery centers.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. While all the medicines are effective, one specific muscle relaxant might work better than others for you. Benzodiazepines, flexeril overdose treatment such as diazepam, affect polysynaptic reflexes at the supraspinal level, act as a spinal cord depressant at the interneuronal level, and inhibit presynaptic acetylcholine release. Clinically, diazepam is administered as an adjunct to anesthesia, in management of clinical signs of tetanus, and in treatment of functional urethral obstruction and urethral sphincter hypertonus in cats.

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As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together. Gastrointestinal side effects include dyspepsia, nausea, emesis, metallic taste, and cholestatic jaundice. Prices for Robaxin (methocarbamol) start around $8 for a bottle of 60 tablets, strength 500 mg. To find the least expensive pharmacy near you, and to obtain a coupon, visit the GoodRX methocarbamol page.

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Then, one or two tablets three to four times per day or more is recommended.
As mentioned above, there is not a significant difference between Robaxin, Fexmid, Amrix, and other muscle relaxants in terms of efficacy in treating acute low back pain, other musculoskeletal pain, and muscle spasms.
For patients dealing with muscle spasms and pain, certain medications that relax the muscles can help in managing discomfort and facilitating recovery.
To talk with a doctor and see if a muscle relaxant is a good solution for you, get in touch with QuickMD today.
Flexeril is one of the most studied muscle relaxants; thus, it has more supporting evidence for its effectiveness.

Comparison studies have not shown one skeletal muscle relaxant to be superior to another. Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions. The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited.

Treatment & Diagnosis

It is used to relax muscles and relieve pain and discomfort caused by muscle injuries. There are no well-done studies to determine the safety of this muscle relaxant during pregnancy, therefore, contact your doctor before using it. Also, it passes into breast milk and may affect the infant in a negative way. This prescription medication is used together with physical therapy, rest, and other ways to relax muscles and relieve discomfort and pain caused by sprains, strains, and other muscle injuries. Flexeril is the most studied drug and hence has more supporting proof of its effectiveness. According to the experiment done on patients, they felt slightly sounder improvements in local pain with Cyclobenzaprine (48% vs. 40%).

Only after oral administration of methocarbamol, guaifenesin is detectable in equine plasma and urine, indicating that first-pass metabolism is necessary for guaifenesin to be produced as a metabolite. Because of their sedative effects, methocarbamol and guaifenesin are regulated by equine sports organizations, and withdrawal periods must be respected. The effect of this muscle relaxant can be felt within half an hour of administration of the dose. According to the FDA, methocarbamol is contraindicated in individuals with a history of drug hypersensitivity to methocarbamol or component products. Intravenous (IV) and intramuscular (IM) formulations may also be used commonly in the postoperative setting.[14][15] one gram can be injected every eight hours by IM or IV route. The dose should not exceed three grams daily and should not be used for more than three consecutive days.